MSP group research interests center around the asymmetric synthesis of small natural products and natural product mimics by exploiting organocatalysis. His research group also focuses on developing new synthetic methods to generate morphologically and functionally complex small chiral organic molecules with biological activity.
ReSeArCh iNtErEsTs
Some of our recent efforts in developing asymmetric organocatalytic strategies are represented below
1. Design of 2-(E)-benzylidine-3-pyrrolidinyl acraldehyde as a potential synthon for asymmetric [4+2]-annulation reactions
Recently MSP research group focussed on developing a robust and sustainable approach for constructing functionally rich optically pure heterocyclic frameworks via [4+2]-addition of in situ generated trienamine from a specially designed 2-(E)-benzylidine-3-pyrrolidinyl acraldehyde as a synthon.
2. Enantioselective synthesis of octahydrofuranoindole core of aspidosperma alkaloids via Diels Alder/reduction- /fluoroetherification reaction sequence
MSP research group very recently successfully devised a method for the synthesis of octahydrofuranoindole core of aspidosperma alkaloids via Diels- Alder/reduction-/fluoroetherification reactions sequence.
3. Employment of N-2,2,2-trifluoroethyl isatinketimines as a potential synthon for asymmetric [3+2]-annulation reactions
The MSP research group is also interested in other aminocatalytic cascade reactions by employing ketimines as a potential synthon for constructing biologically potential spiroheterocycles. MSP group reported the first employment of N-2,2,2-trifluoroethyl isatinketimines as a 1,2-dipolarophile in contrast to the literature.
